As long as you are using a Juiced Bike with an LCD display, the 52V battery can be used. The 52V battery pack is designed to be interchangeable with that of the 48V bikes that use an LCD display (CrossCurrent S and RipCurrent S). These bikes were actually initially designed to use the 52V system. The motor, controller, LEDs, and software are all capable of handling the increased voltage.
However, some of our Step-Thru models do not have the vertical space required to fit the 52V battery.